Specifically, in head and neck squamous cell carcinoma (HNSCC), the overexpression of ALKBH5 suppresses RIG‐I‐mediated IFNα secretion via the IκB kinase epsilon/TBK1/interferon regulatory factor 3 (IRF3) signaling pathway, which is closely related to tumor cell programmed cell death. The gene discussed is ALKBH5; the disease is head and neck squamous cell carcinoma.