A photosensitive, dual‐targeting nanoparticle system (M.RGD@Cr‐CTS)–small interfering RNA‐targeting YTHDF1 (siYTHDF1) nanoparticles target TAMs to deliver the drug, altering the STAT3/STAT1 balance, reducing IL‐10, increasing IL‐12 and IFN‐γ, and promoting CD8+ T cell infiltration, highlighting the potential of RNA interference in cancer immunotherapy.323. This evidence concerns the gene YTHDF1 and cancer.