Specifically, in head and neck squamous cell carcinoma (HNSCC), the overexpression of ALKBH5 suppresses RIG‐I‐mediated IFNα secretion via the IκB kinase epsilon/TBK1/interferon regulatory factor 3 (IRF3) signaling pathway, which is closely related to tumor cell programmed cell death. This evidence concerns the gene IRF3 and neoplasm.