In NSCLC, four TRM cell subgroups were identified: PD‐1−Tim‐3−TRM cells, PD‐1+Tim‐3− TRM cells, PD‐1−Tim‐3+ TRM cells, and PD‐1+Tim‐3+ TRM cells. Among these, PD‐1+Tim‐3− TRM cells exhibited the highest level of cytotoxicity. This evidence concerns the gene HAVCR2 and non-small cell lung carcinoma.