Coronary atherosclerosis was also achieved in a series of mouse models that combined deficiency of either the LDLR or the apoE genes with the gene encoding the HDL receptor SR-BI (Scavenger receptor Class B Type 1) [51,52], or genes that interact with or are activated by SR-BI in endothelial cells such as the endothelial nitric oxide synthase (eNOS) [53] and the PDZ containing 1 (PDZK1) [54]. This evidence concerns the gene NOS3 and coronary atherosclerosis.