Although the importance of 14-3-3 Eta proteins in several rheumatic diseases has been evaluated, its significance in the early identification of uveitis linked to JIA and RA is still being debate.[2,11] In this study, serum 14-3-3 Eta protein was compared to other biomarkers, such as RF and Anti-CCP, to assess its potential as a novel biomarker for the early diagnosis of uveitis in Egyptian patients with JIA and RA, as well as its correlation with disease activity, was conducted. The gene discussed is YWHAQ; the disease is juvenile idiopathic arthritis.