To the best of our knowledge, this study is the first to highlight and explore the role of 14-3-3 Eta protein biomarker in the early detection of uveitis among RA patients with a highly sensitive, specific, and accurate cutoff point, as, at 14-3-3 Eta protein biomarker serum level of 57.5, we could predict the occurrence of uveitis, and patients must be screened with a thorough ophthalmologic investigation at this cut-off point. Here, EDNRA is linked to rheumatoid arthritis.