Amalraj et al. [18] and Pourhabibi Zarandi et al., in separate studies, showed that the administration of curcumin led to reduced levels of ESR and CRP, in contrast to those who received placebo.[19] Corroborating the findings of our study, other studies have shown a noteworthy reduction in CRP, ESR, and DAS.[11,13,15] Javadi et al. presented findings indicating positive outcomes, though not statistically significant, regarding changes observed in DAS28 among patients with RA treated with 40 mg nano-micelle curcumin three times per day over 12 weeks. The gene discussed is CRP; the disease is rheumatoid arthritis.