Kurbegovic et al. found that constructing full-length genomic Pkd1 into a Pkd1-inactivated mouse model rescued Pkd1-deficient mice.[34] According to what Kurbegovic et al. found in their study, the introduced high copy number renal targeting genesSB Pkd1 and Pkd1Minigene showed expression levels similar to those of the endogenous Pkd1 gene, produced functional PC1 proteins in vivo that delayed or even eliminated renal cyst formation, and extended lifespan by up to 4-fold to completely rescue PKD mice. The gene discussed is PKD1; the disease is cystic kidney disease.