PKD1 and autosomal dominant polycystic kidney disease: Further studies showed that adult chimeric mice derived from iPSCs containing the repaired Pkd1 gene (+/R+) had a significantly lower frequency of renal cyst formation than mice derived from iPSCs containing the original Pkd1(+/-) mutation and were not significantly different from normal mice.[36] This provides a new therapeutic avenue for genetic diseases such as ADPKD, where genetic defects are corrected by mitotic recombination-mediated gene repair.