Researchers transduced anti-RAGE shRNA into ADPKD mice via adenoviral vectors and demonstrated that kidney size, cystogenesis, and renal function were improved in ADPKD mice with downregulation of the RAGE gene.[32] These results suggest that the RAGE-related signaling pathway is closely related to the pathogenesis of PKD, and the RAGE gene may be a new potential therapeutic target for PKD. The gene discussed is AGER; the disease is autosomal dominant polycystic kidney disease.