Disruptions in these genes impair the functions of their protein products, promoting abnormal cell proliferation, differentiation, inflammation, epigenetics, and fluid secretion, culminating in cyst development and progressive renal decline.[7,8] The widespread distribution of Pkd1 mutations across its coding region further complicates the genetic landscape of ADPKD. The gene discussed is PKD1; the disease is autosomal dominant polycystic kidney disease.