P2RX7 and autosomal recessive polycystic kidney disease: Using CRISPR/Cas9 technology, Arkhipov et al. performed global knockdown of the P2rx7 gene in an ARPKD rat model and found that cyst growth was significantly slowed down in ARPKD rats after knockdown of the P2rx7 gene compared to controls carrying the P2rx7 gene.