,29,51,54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64 Interestingly, MYCN was reported to regulate the expression of MDM2,65 and MDM2's oncogenic functions may contribute to MYCN-driven tumorigenesis.66, 67, 68, 69, 70 Targeting both MYCN and MDM2 by combining treatments or using dual inhibitors may hold promise as a potential approach for cancer patients with MYCN amplification. This evidence concerns the gene MDM2 and cancer.