MYCN and Familial prostate cancer: In lung cancer, even though MYCL is the major MYC family member detected, MYCN was confirmed to regulate the chemoresistance of small-cell lung cancer and promote the proliferation of non-small-cell lung cancer.88, 89, 90 Neuroendocrine prostate cancer (NEPC), comprising approximately 2% of all prostate cancers,91 is commonly castration-resistant and is characterized by the down-regulation of the androgen receptor and prostate-specific antigen expression, which are associated with a poorer prognosis.92