MYCN and neuroblastoma: Additionally, these insights have been substantiated by compelling evidence demonstrating a noteworthy delay in tumor growth within the SK-N-BE (2) neuroblastoma xenograft model and an extension of survival in a TH-MYCN transgenic mouse model of neuroblastoma (established by targeted expression of the human MYCN oncogene in neuroectodermal cells under the control of rat tyrosine hydroxylase promoter).155