Two of these pathways are likely to play a major role in DLDD and GSD1a pathophysiology: methionine metabolism (https://www.smpdb.ca/view/SMP0000033, enrichment significance p < 0.003, FDR < 0.11), and spermidine and spermine biosynthesis (https://smpdb.ca/view/SMP0000445, enrichment significance p < 0.004, FDR < 0.11). The gene discussed is G6PC1; the disease is pyruvate dehydrogenase E3 deficiency.