P2RY12 and atrial fibrillation: The 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization recommends discontinuation of aspirin treatment 1 to 4 weeks post-PCI with maintenance of P2Y12 inhibitor plus DOAC or warfarin therapy to reduce bleeding risk in patients with atrial fibrillation taking oral anticoagulant therapy.8