The scope of NP2's influence spans a wide array of conditions, including neurodegenerative diseases such as Alzheimer's and Parkinson's, neuropsychiatric disorders such as schizophrenia and bipolar disorder, and other neurological conditions such as neuropathic pain, epilepsy, amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD). Here, NPTX2 is linked to amyotrophic lateral sclerosis.