The main haplotype was linked to four variants (rs12517451, rs863216, rs245100 and rs1650697, R2 > 0.95) and was associated with several cortical morphology-related traits assessed using neuroimaging.26-29 This cortical morphology-related haplotype was also in strong linkage disequilibrium (i.e. R2 > 0.95) with one of the MSH3 Huntington’s disease modifier signals (i.e. rs701383). The gene discussed is MSH3; the disease is juvenile Huntington disease.