Both LIG1 (lead variant: rs274876) and RRM2B (lead variant: rs2061299) were associated with the same neurobiological trait, neurofibrillary tangles.32 The LIG1 rs274876 neurofibrillary tangle-associated variant is in high LD with the intronic Huntington’s disease AOO LIG1 rs3730945 variant (R2 = 0.82), while the RRM2B signal was independent of the Huntington’s disease AOO RRM2B locus. This evidence concerns the gene LIG1 and Neurofibrillary tangles.