Juvenile-onset pure spastic paraplegia-80 (SPG80) is a type of HSP characterized by symptom onset at the age of 11 and is commonly associated with SPAST or KIF1A gene mutation [17]. The proband in this case report exhibited the exact onset of symptoms but involved a different gene mutation, the UBAP1. As previously stated, UBAP1 gene mutation accounts for 1.7% of 417 families with HSP, and 20 of its variants are associated with SPG80 [10,11]. Here, SPAST is linked to hereditary spastic paraplegia.