Indeed, these Canadian recommendations, published in 2016, find an echo in the VISION NT-proBNP study, published 4 years later in 2020.7 Pre-operative NT-proBNP measurements from 10 402 patients showed that compared with pre-operative NT-proBNP <100 ng/L (the reference group), values of ≥100 to <200, ≥200 to <1500, and ≥1500 were associated with adjusted HRs of 2.27 (95% CI 1.90–2.70), 3.63 (95% CI 3.13–4.21), and 5.82 (95% CI 4.81–7.05), and corresponding incidences of the composite of vascular death and myocardial injury (12.3, 20.8, and 37.5%, respectively). This evidence concerns the gene NPPB and injury.