MiR-1271-3p has been studied and found to have a direct pathway in regulating calcium/calmodulin-dependent protein kinase 2 (CaMKK2).20 It also contributes, together with zinc finger antisense 1 (ZFAS1) and hexokinase 2 (HK2), in regulating growth in glioma tissues.21 Both studies showed that lower expression of CaMKK2 and ZFAS1 were associated with upregulation in miR-1271-3p while interacting with HK2, therefore constraining proliferation, migration, and apoptosis of tumor cells. This evidence concerns the gene HK2 and central nervous system cancer.