NFKB1 and central nervous system cancer: This, in turn, lowers NF-kB activity and increases resistance to apoptosis.17 In glioma patients, NF-kB is activated more in HGG.18 NF-kB has a role in mediating inflammatory cytokines regulation, and a study has found an increased miR-518 expression in human endothelial cells that have been exposed to oxidative stress and inflammation.