To further investigate the role of GDAP1 in maintaining redox balance within mitochondrial MCSs, we conducted the same experiment by transfecting TOMM20-pHluorin2 into fibroblasts from Patient 1 and another CMT patient (P3) who carries a heterozygous p.Arg104Trp variant in the MFN2 gene for the OMM Mitofusin 2. The gene discussed is MFN2; the disease is Charcot-Marie-Tooth disease.