Inflammation induced by TIBs, especially plasmablasts, has been shown to recruit CD8 + T cells into the tumor microenvironment via the expression of T cell–recruiting chemokines, thereby enhancing T cell-driven anti-tumor immunity.45 This dual role of TIBs, contributing to both tumor promotion and suppression, underscores the complexity of the tumor microenvironment and suggests that the effects of TIBs on tumor behavior may depend on the specific context and interactions within the tumor milieu. The gene discussed is CD8A; the disease is neoplasm.