AKT1 and Alzheimer disease: Its proper expression is essential forhost defense and is tightly regulated at multiple levels, including chromatinstructure, transcriptional control, and post-transcriptional modifications [39].Due to the numerous factors influencing IL-6 expression, its trans-signalingmechanism can activate various signaling pathways, includingJanus kinase/Signal transducer and activator of transcription(JAK/STAT3) and Phosphatidylinositol 3-kinase and protein kinase B/Akt(PI3K-PKB/Akt), leading to the development of conditions such as cancer, multiplesclerosis, and Alzheimer’s disease [40].