Globally, cardiovascular disease (CVD) affects ∼9% of individuals and is responsible for one-third of all deaths and substantial disability.1 Trends over the last two decades suggest that increased body mass index (BMI)2,3 is a key contributor to increasing atherosclerotic CVD (ASCVD) risk worldwide.4–6 Atherosclerosis results from the accumulation of apoB-containing lipoproteins (mostly LDL particles)7 within the vessel wall, which may be accelerated by the presence of additional risk factors. This evidence concerns the gene APOB and atherosclerosis.