TNIP3 and hydrops fetalis: Previous research indicates that TNIP3 is a negative regulator of myocardial hypertrophy, significantly up-regulated in neonatal rat cardiomyocytes stimulated by phenylephrine and in mouse hearts undergoing TAC surgery.16 Based on this, we believe that TNIP3 may play a crucial role in the occurrence and development of VAs following HF.