Nonetheless, together these data provide strong evidence for the involvement of TGM2 in dermal fibrosis in scleroderma through the regulation of TGF‐β and the reciprocal modulation by TGM2 of TGF‐β functional activity, thus revealing that there are several ways by which TGM2 can promote fibrosis. The gene discussed is TGM2; the disease is scleroderma.