In vivo studies showed that TGM2 knockout (KO) mice exhibited attenuated lung fibrosis following bleomycin challenge21 and in a unilateral ureteral obstruction model of chronic kidney disease,27 and the addition of a small‐molecule TGM2 inhibitor reduced both glomerular and tubulointerstitial fibrosis in a rodent model of diabetic nephropathy.20 Here, TGM2 is linked to Ureteral obstruction.