Moreover, the presence of BB7 was able to inhibit the levels or activity of TGF‐β secreted by scleroderma fibroblasts, thus attenuating the endogenous Smad signaling observed in these cells thereby preventing the increase in Col‐1 expression and reducing the level of myofibroblast marker αSMA in the cells. The gene discussed is TGFB1; the disease is scleroderma.