PANO1 and neoplasm: Moreover, while Pano treatment significantly reduced tumor growth rate in both WT and RR FaDu tumors compared to vehicle control (WT [P = 0.035], RR [P = 0.039]), we observed greater Pano/control fold-change difference in RR FaDu compared to WT (WT = 2.15; RR = 3.15) (Fig. 3c).