CDKs play a crucial role in RA FLSs-mediated pathogenesis, primarily by driving metalloproteinases (MMPs) release from FLSs, as result of CDK3,CDK4/6 or CDK9 activity139,528,529 and secondly, by promoting FLSs proliferation through the miR-124a-CDK2 axis.530 CDKs are also involved in controlling several RA-neutrophils essential functions. Here, CDK4 is linked to rheumatoid arthritis.