CDK1 and hepatocellular carcinoma: CDK1 expression is significantly increased in several tumor types compared to normal tissues, particularly in breast, colon, lung, prostate, head and neck cancer, liver carcinoma, pancreatic adenocarcinoma, and glioblastoma.291,292 At genomic levels CDK1 is amplified in 7% of uterine carcinosarcoma cases and mutated in 3% of melanoma tumors.