On the other side, by binding and blocking the activity of the transcription factor RUNX1, CDK6 can prevent myeloid cells differentiation.333 CDK6 also impact on local microenvironment by regulating tumor angiogenesis in concert with STAT3 to induce p16INK4a expression, or with AP-1 transcription factors and upregulate VEGFA, promoting tumor vascularization in a D-type cyclins independent manner.334. The gene discussed is CDKN2A; the disease is neoplasm.