Prematurely terminated RNAs (ptRNAs) accumulate in CDK13-mutated melanoma due to decreased CDK13-dependent S475 phosphorylation of ZC3H14, a component of the PAXT complex involved in normal nuclear ptRNA degradation.227 This accumulation results in the translation of truncated proteins, contributing to the oncogenic phenotype.227. This evidence concerns the gene CDK13 and melanoma.