CDK2 and neoplasm: In tumors with very high cyclin E1 expression, the cyclin E1-CDK2 complex mediates cell cycle progression, chromosomal instability, and genomic instability, resulting in chromosome mis-segregation, polyploidy, and genomic deletions.308 Inhibition of CDK2 in HGSOC tumors may be crucial to block tumor growth and prevent the development of platinum-resistant recurrences.