In breast and colon cancer cells CDK15 can mediate resistance to TRAIL-induced apoptosis leading to cell survival.458 Yet other analyses, in breast tumor specimens indicated that CDK15 protein level is down-regulated in breast cancer and that CDK15 overexpression negatively modulates cell motility, repressing their migratory and invasive capabilities, leaving unclear its role(s) in this type of tumors.459. Here, CDK15 is linked to malignant colon neoplasm.