EZH2 and neoplasm: Overexpressed CDK20 promotes HCC progression by activating the Wnt/β-catenin/TCF/EZH2 signaling pathway, creating a positive transcriptional feedback loop that enhances AR signaling.433 Hepatic activation of EZH2, dependent on CDK20, stimulates IL-6 production and the accumulation of immunosuppressive T cells.434 Hence, inhibition of CDK20 may disrupt this immunosuppressive tumor microenvironment and enhance the therapeutic efficacy of immune checkpoint blockade.