Dysregulation of SEs is common in cancer, with super-enhancers often acquired at oncogene drivers (e.g., MYC) during tumor pathogenesis.336 These alterations lead to a transcriptionally dysregulated state in cancer, termed “transcriptional addiction,” resulting in a disproportionate dependency on various components of the core transcriptional machinery, including tCDKs.337 This phenomenon suggests that cancer cells may be more responsive than their normal counterparts to transcriptional inhibition. The gene discussed is MYC; the disease is cancer.