CDK16 is reported to be widely overexpressed in several cancer types, including lung, breast, prostate, melanoma and liver cancers.462 Higher CDK16 expression levels were reported in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) respect to matched normal tissues.463 Higher CDK16 levels correlated with poor clinical outcomes, significantly associating with low overall survival (OS). The gene discussed is CDK16; the disease is liver cancer.