CDK7 and triple-negative breast carcinoma: Interestingly, triple-negative breast cancers (TNBC), which display higher aggressiveness, advanced genetic complexity, and a characteristic gene expression program compared to hormone receptor-positive breast cancers, are exceptionally dependent on CDK7.356 TNBC shows a profound dependence on CDK7, which mediates this transcriptional addiction to a specific cluster of oncogenic genes, such as MYC, SOX9, FOXC1, EGFR, and FOSL1, promoting cell proliferation, migration, and stemness.