CDK6 deletion leads to hematopoietic defects, including thymus and spleen hypoplasia, and reduced megakaryocyte and erythrocyte numbers.56 Combined CDK4/6 knockout results in late embryonic or postnatal lethality due to severe anemia, highlighting their importance in hematopoietic lineage development.56 CDK6 is predominantly localized in the cytoplasm, with a smaller nuclear fraction, indicating additional functions beyond cell cycle progression, such as rapid cell cycle entry post-reactivation in CD8 memory cells and cytoskeletal rearrangement in astrocytes.62 This evidence concerns the gene CDK6 and anemia (phenotype).