This observation aligns with other studies reporting gains of the CDK8-associated 13q12.13 genomic region up to 60% of colorectal cancers.361,362 Further research showed that CDK8 levels increased in patients with advanced CRC stages (III/IV), suggesting the possible involvement of CDK8 in the advanced stages of CRC development and progression. This evidence concerns the gene CDK8 and colorectal carcinoma.