CDK8 and cardiovascular disorder: Individuals affected by distinct missense CDK8 mutations exhibit overlapping phenotypes, including congenital heart disease or dilated cardiomyopathy (DCM).496 CDK8, as part of the kinase submodule of the Mediator complex (MED12, MED13, CDK8, and cyclin C), plays a role in maintaining normal cardiac function and is involved in cardiovascular diseases.497