CCND3 and acute lymphoblastic leukemia: A relevant role of CDK6, likely in complex with cyclin D3, is its involvement in the DNA damage response through the regulation of ATR that opened the way to consider the use of CDK4 and CDK6 inhibitors association with chemotherapy.66 Also in complex with cyclin D3 CDK6 affects metabolic pathways in T-ALL by phosphorylating glycolytic enzymes, redirecting glycolytic intermediates, and increasing reactive oxygen species and apoptosis upon inhibition.335