An increased amount of cyclin D1/CDK4 complexes has been associated with cardiac hypertrophy.486 Moreover, following cardiac injury, targeting the cell cycle inhibitor p16INK4a leads to CDK4/6-mediated proliferation, resulting in myocardial regeneration and repair both in vitro and in vivo.487 Furthermore, CDK4 has been identified as a direct transcriptional target of GATA4, a gene known to regulate cardiomyocyte differentiation and proliferation.488. The gene discussed is CDK4; the disease is cardiac hypertrophy.