CDK4 and amyotrophic lateral sclerosis: Bajaj and colleagues studied the localization of CDK5 in different familial cases of amyotrophic lateral sclerosis (ALS), observing accumulation of CDK5 in perikaryon (the cell body, non-process portion of a neuron, containing the cell nucleus), of degenerating neurons and co-localization with lipofuscin, which is associated to oxidative stress as part of the ALS pathogenesis.470 Furthermore, a mutant murine model expressing the superoxide variant SOD1(G37R) linked to ALS was used to investigate the role of CDK4 and CDK5 in this pathology.