ETS2 and Syndactyly - telecanthus - anogenital and renal malformations: Among these, the most extensively studied is ETS2, a transcription factor involved in cellular proliferation and development.195 ETS2 phosphorylation by CDK10 reduces its transactivation and enhances its proteasomal degradation.196 Furthermore, mutations in cyclin M associated with STAR syndrome have been correlated with elevated ETS2 protein levels.191 Moreover, CDK10 could directly associates with RNA polymerase II CTD, c-MYC, and RB, thereby controlling transcription and cell proliferation.193