CDK15 and breast cancer: In breast and colon cancer cells CDK15 can mediate resistance to TRAIL-induced apoptosis leading to cell survival.458 Yet other analyses, in breast tumor specimens indicated that CDK15 protein level is down-regulated in breast cancer and that CDK15 overexpression negatively modulates cell motility, repressing their migratory and invasive capabilities, leaving unclear its role(s) in this type of tumors.459