Recently, CDK20 has been implicated in the activation of the mTORC1/4E-BP1/S6K/SREBP1 cascades through GSK3β phosphorylation, sustaining a proinflammatory signaling pathway that promotes non-alcoholic steatohepatitis (NASH)-related hepatocarcinogenesis.435 In HCC patients with hepatitis B virus (HBV) infection, higher CDK20 levels are observed, which are dependent on the HBx viral protein.436 The involvement of CDK20 in liver carcinogenesis and its oncogenic activity in multiple other cancer types, render CDK20 a promising therapeutic target. The gene discussed is RPS6KB1; the disease is metabolic dysfunction-associated steatohepatitis.