BCL2 and neoplasm: Although it has been identified as a potential oncogene in colorectal cancer (CRC), where its high expression is a prognostic factor of poor survival and correlates with tumor growth and reduced chemosensitivity by upregulating the antiapoptotic Bcl-2,387,388 it seems to act mainly as tumor suppressor in different type of cancer including breast,389 lung,390 and thyroid cancer,391 hepatocellular carcinoma (HCC)392 and glioma.393