Congenital heart defects, facial dysmorphism, and intellectual developmental disorder (CHDFIDD) is a newly described syndrome caused by these de novo variants in CDK13.494 Among the affected individuals, 81% displayed some form of cardiac anomaly, with 44% having additional structural cardiac issues, ranging from left pulmonary artery defects to bicuspid aortic valves.494 In a large cohort of 610 patients with congenital cardiac diseases, seven patients with de novo missense mutations in the CDK13 gene were identified, suggesting an involvement of CDK13 in these conditions.495. This evidence concerns the gene CDK13 and congenital heart disease.