CDK8 inhibition upregulates STAT1-target genes and decreases cell viability in JAK-STAT dependent myeloproliferative neoplasms and AML.372,373 CDK8 is indispensable for the maintenance of established leukemic cell lines, including BCR-ABL+ leukemias (B-ALL). This evidence concerns the gene CDK8 and acute myeloid leukemia.