CDKs also influence the activity of transcription factors such as NF-κB and STAT3, which are involved in the expression of pro-inflammatory cytokines and chemokines.546 Using different psoriasis-like mouse models, Muller and collaborators identified a novel proinflammatory signaling pathway driven by CDK4 and CDK6 that, through phosphorylation of EZH2 in keratinocytes, triggered a methylation-induced activation of STAT3. This evidence concerns the gene CDK4 and psoriasis.