TP53 and breast cancer: CDK16 could phosphorylate TP53 at Ser315, which is trapped in the cytoplasm inhibiting its transcriptional activity, promoting cell proliferation, survival and radio-resistance.464 Moreover, the phosphorylation of Protein Regulator of Cytokinesis (PRC1) at Thr481 by CDK16 prevents its nuclear localization, and promotes cell proliferation.465 In accordance, CDK16 knockdown suppressed or reduced cell growth in several cancer types, including, among the others, breast cancer, hepatocellular carcinoma, renal cancer, and melanoma.273,462