However, CDK8 possess both oncogenic and tumor-suppressive roles in different contexts, due to its function as modulator of transcription factor activity and as a regulator of Pol II- Mediator complex interactions.141 In contrast to CDK8, scarce information is available about unique CDK19 roles in cancer, and whether it compensates for loss of CDK8 remains largely unknown. The gene discussed is CDK8; the disease is cancer.