CDK20 and lung carcinoma: Additionally, high CDK20 levels contribute to ovarian cancer progression by upregulating cyclin D1 expression, thereby promoting cell proliferation.431 In lung cancer tissues, CDK20 overexpression enhances the KEAP1-NRF2 pathway, promoting tumor progression and radio-chemoresistance by mitigating oxidative stress and exerting a cytoprotective role.432