Although it is widely recognized that exogenous LH activity is crucial for restoring spermatogenesis in hypogonadal men with inadequate LH production or action (e.g., HH males), the role of LH in hypogonadal infertile males with no evident LH deficiency, like patients diagnosed with idiopathic oligozoospermia or non-obstructive azoospermia, is still a subject of controversy [1] and currently an active area of research. The gene discussed is PLOD1; the disease is Azoospermia.