For example, CDK9 and MNK enhance AML cell survival and proliferation through phosphorylation of eIF4E and activation of the PI3K/Akt/mTOR pathway.54–56 Additionally, research indicated that that FASN promotes tumor proliferation and invasion, such as gastrointestinal stromal tumor and liver cancer, by activating the Akt/mTOR pathway.57,58 Furthermore, SREBF1 is directly regulated by the PI3K/Akt/mTOR pathway.59 Our findings also indicate that CDK9 and FASN can regulate the Akt/mTOR/SREBF1 pathway in Kasumi-1 and U937 cells. The gene discussed is SREBF1; the disease is acute myeloid leukemia.