It has been reported that oestrogen makes an important contribution by affecting NLRP3, and that oestrogen can inhibit the development of multiple diseases such as asthma, neurological disorders, asthma, bone disease, cancer etc. by suppressing NLRP3 inflammatory vesicles, but it can also promote disease progression by facilitating the activation of inflammatory vesicles.87 The gene discussed is NLRP3; the disease is asthma.