IL6 and Alzheimer disease: Interestingly, effect sizes for the associations between IL-6 PRS and AD incidence differed between the two cohorts, with relatively larger estimates observed in the HELIAD cohort (a 1 SDU increase in IL-6 PRS was associated with a 30–43% increase in the risk for AD or aMCI), compared to the UKB (a 1 SDU increase in IL-6 PRS was associated with a 6–8% increase in the risk for AD).