In the present work, using the summary statistics of a genome-wide meta-analysis [15], we calculated a PRS to estimate genetic predisposition to increased circulating levels of IL-6, and studied its association with incident AD or its prodromal stage, amnestic mild cognitive impairment (aMCI) [16], in two independent prospective cohorts of community-dwelling individuals without dementia. This evidence concerns the gene IL6 and Alzheimer disease.