This agrees with previous studies showing that L‐carnitine prevents pulmonary vascular remodeling and right ventricular remodeling in rodent models of idiopathic pulmonary hypertension.[22] We observed that endothelial Cpt1a deletion led to the spontaneous development of EndoMT and pulmonary vascular remodeling under normoxia. This evidence concerns the gene CPT1A and pulmonary arterial hypertension.