Herein, we found that in HCC, METTL3 was correlated with ferroptosis and radiosensitivity, and further studies showed that METTL3 could directly regulate the transcription of the ferroptosis regulator SLC7A11 through m6A/IGF2BP2, and indirectly regulate the stability of SLC7A11 protein through m6A/YTHDF2/SOCS2. This evidence concerns the gene YTHDF2 and hepatocellular carcinoma.