However, knockdown of METTL3 significantly reduced the 3’UTR activity of SLC7A11 (Fig. 5F), and mRNA stability of SLC7A11 in METTL3 knockdown HCC cells was significantly less than that in control after Act-D treatment (which blocks the production of new RNA transcripts and is recognized as a commonly used drug to detect the rate of degradation of existing RNAs [34, 35]) whether or not exposed to IR (Fig. 5G, H, Supplementary Fig. S3F). Here, SLC7A11 is linked to hepatocellular carcinoma.