Mechanistically, METTL3 regulates the RNA stability of SLC7A11 through an IGF2BP2-dependent manner and indirectly controls the ubiquitination level of SLC7A11 via the m6A/YTHDF2/SOCS2 axis to subsequently regulate ferroptosis in HCC cells. This evidence concerns the gene IGF2BP2 and hepatocellular carcinoma.