In addition, to further understand the role of SOCS2 in METTL3-mediated regulation of SLC7A11 expression and ferroptosis, we further knocked down SOCS2 on the basis of knockdown of METTL3, and the results showed that the double knockdown group significantly reduced intracellular ROS levels (Fig. 9K), lipid peroxidation levels (Fig. 9L) and radiosensitivity of HCC cells (Fig. 9M). This evidence concerns the gene SOCS2 and hepatocellular carcinoma.