For instance, YTHDF2 modulates the m6A methylation of OCT4 mRNA to promote the cancer stem cell phenotype and cancer metastasis [23]; while METTL3 promotes HCC progression through an m6A-YTHDF2-dependent post-transcriptional silencing of SOCS2 [24]. Here, YTHDF2 is linked to hepatocellular carcinoma.