Another study found that the positive rate of IL-8 expression and its score in keloid were significantly higher than those in normal skin, the microvessel count in the tissues with IL-8 positive expression was higher than that in the tissues with IL-8 negative expression, and the expression score was positively correlated with the microvessel count, suggesting that fibroblasts and vascular endothelial cells of pathological keloid tissue synthesize and secrete IL-8, promoting the angiogenesis of keloid tissue, and leading to abnormal hyperplasia of keloid.23 The gene discussed is CXCL8; the disease is keloid.