TGFB1 and keloid: TGF-β is involved in inflammation, angiogenesis, proliferation of fibroblasts, collagen synthesis and extracellular matrix remodeling.61, 62, 63 TGF-β was expressed in dermal fibroblasts, inflammatory cells, and endothelial cells of keloids.64, 65 TGF-β induces polypyrimidine tract-binding protein to alter fibroblasts proliferation and fibronectin deposition in keloid.66