This article reviews in detail the possible roles of proinflammatory cytokines (IL-1β, IL-4, IL-6, IL-8, IL-13, IL-17, IL-18, IL-22), anti-inflammatory cytokines (IL-10, IL-24, IL-37), chemokines (CXCL4, CX3CL1, CX3CR1, CXCL10, CXCL11, CXCR3, CCR2) and growth factors (EGF, VEGF, TGF-β, bFGF) in the pathogenesis of keloid (Figure 1, Figure 2). This evidence concerns the gene IL4 and keloid.