The addition of phosphatidylinositol 3-kinase (PI3K), mitogen activation protein kinase (MAPK), Specificity protein 1 (Sp1), and mammalian target of rapamycin (mTOR) inhibitors inhibited IL-18 secretion in keloid cocultures, suggesting their potential clinical use in the treatment of keloid.34 Here, WNK2 is linked to keloid.