Consuming 40 g of dark chocolate (containing more than 85 % cocoa) daily for 2 weeks decreased the levels of soluble NADPH oxidase isoform 2 (NOX2)-derived peptide, which serves as a marker of NOX2 activation, as well as serum cytokeratin-18 and ALT, with antioxidant activity achieved by down-regulating NOX2 in patients with MASH [198]. This evidence concerns the gene CYBB and metabolic dysfunction-associated steatohepatitis.