GSK3B and Hyperammonemia: Instead, these modifications are lost under high ammonia concentrations, probably due to ammonia negative effect on cell functions, signal transduction, as well as on the phosphorylation status of some proteins as a consequence of changes in pH or membrane potential.[45, 46, 47] The noncanonical degradation of β‐catenin during hyperammonemia was also observed in HEK cells where the degradation of β‐catenin during hyperammonemia occurs through a mechanism IKK dependent but GSK3β independent.[48]