IFI16 and infection: In terms of VISORs commonly upregulated in both CD4+ T and myeloid cells upon productive infection, these included sensors of HIV capsid (PQBP1 and MX2) and DNA (TLR9, AIM2, IFI16, cGAS, and pIRF3) and restriction factors targeting reverse transcription (SAMHD1 and PAF1), nuclear import (MX2), integration (TRIM28), transcription (TRIM28, IFI16, and BRD4), and translation (IFITM1) (Figures 6E and 6F).