CD4 and HIV infectious disease: Our data also suggested CD4+ Tfh to highly express VISORs (Figures 2D and 2E), but this was counterintuitive given that this subset has been reported to be a major target for HIV infection and persistence, particularly within LNs.47,52 To examine this more closely, we next compared VISOR expression between CD4+ Tfh and CD4+ non-Tfh Tm from LNs.