To the best of our knowledge, this is the first study to report the possible role played by MALAT1 and miR-155 in BD pathogenesis in Egyptian patients, with reference to the disease incidence and activity, thus, emphasizing their importance for a better understanding of the disease biology and offering promising molecular diagnostic and prognostic markers, as well as, future treatment targets. This evidence concerns the gene MALAT1 and Behcet disease.