Despite novel insights into pathogenesis in recent years, biomarkers for CRP-negative pericarditis, such as SAA or IL-6, are still an unmet need and this can be an intriguing area of research, considering the possible role of IFN gene signature and the possible genetic regulation of CRP response in other immunological conditions, such as SLE. Here, IL6 is linked to systemic lupus erythematosus.