Despite novel insights into pathogenesis in recent years, biomarkers for CRP-negative pericarditis, such as SAA or IL-6, are still an unmet need and this can be an intriguing area of research, considering the possible role of IFN gene signature and the possible genetic regulation of CRP response in other immunological conditions, such as SLE. This evidence concerns the gene IFNA1 and systemic lupus erythematosus.