Studies also described a higher rate of pleural and pericardial effusions in patients with high D-D levels during the first attack, with a trend toward cardiac tamponade [12, 72, 75]; in patients with pericardial effusion following coronavirus disease, Begic et al. showed a correlation between DD and CRP levels and pericardial effusion, respectively around the right atrium and next to the right ventricle-free wall; they proposed that these findings could indicate endothelial dysfunction and microthrombosis of the pulmonary circulation [76]. This evidence concerns the gene CRP and cardiac tamponade.