Overall, these findings demonstrate that FT538 iPSC‐NKs potently induce apoptosis in AML cell lines representing a variety of AML subtypes and cytogenetic presentations, including those with FLT3 (Molm‐13, Molm‐14, MV4‐11) and TP53 mutations (Kasumi‐1). This evidence concerns the gene FLT3 and acute myeloid leukemia.