Overall, these findings demonstrate that FT538 iPSC‐NKs potently induce apoptosis in AML cell lines representing a variety of AML subtypes and cytogenetic presentations, including those with FLT3 (Molm‐13, Molm‐14, MV4‐11) and TP53 mutations (Kasumi‐1). The gene discussed is TP53; the disease is acute myeloid leukemia.