Together with an independent article in the same issue [4], Koenig and colleagues provide insights into allergen‐specific B cell memory by identifying class‐switched IGHE+ MBC2s with a strong type 2 phenotype, which appears to be generated mainly in GCs, as potential precursors of IgE PCs in allergen‐specific recall responses in allergy, but also after allergen‐specific immunotherapy (AIT). This evidence concerns the gene IGHE and Allergy.