The RUNX family is marked by evolutionary conservation and is required for the tissue-specific lineage commitment across a range of biological entities.12 RUNX1 has received attention for its potential role in modulating angiogenesis, a critical process in tumor growth and metastasis.13 However, the relationship between RSK4, a kinase with a significant influence on cell behavior, and RUNX1, especially in the context of RCC, is not yet fully understood. The gene discussed is RPS6KA6; the disease is renal cell carcinoma.