Importantly, compared with low RSK4 expression, high RSK4 expression was correlated with shorter overall survival (OS) of patients with ccRCC.While this study opens new avenues for research, it also highlights the importance of a comprehensive understanding of the role of RSK4 in RCC (Figure 1c and Table 1). Here, RPS6KA6 is linked to nonpapillary renal cell carcinoma.