When combining the results from both filters, the time effects on tear osmolarity, MMP-9 grades and positivity, TBUT, NEI scales, SICCA scores, Oxford scores, LWE grades, upper and lower lid margin telangiectasia scores, upper and lower lid MG expressibility/secretion scores, and OSDI scores were significant (tear osmolarity: p = 0.001; MMP-9 grades: p = 0.017; MMP-9 positivity: p = 0.003; all other measurements: p < 0.001). The gene discussed is MMP9; the disease is Telangiectasia.