INS and contact dermatitis: These skin issues are nail discoloration, acrochordons, acanthosis nigricans, skin tags, diabetic dermopathy, rubeosis faciei, pruritus, granuloma annulare, necrobiosis lipoidica, scleroedema diabeticorum, bullosis diabeticorum, perforating dermatosis, calciphylaxis, eruptive xanthoma, and infections [28], as well as local reactions, contact dermatitis, and lipohypertrophy at insulin injection sites.