In order to avoid the heterogeneity—and, hence, inaccuracy—of immunohistochemical analysis, Ramos-Santillan et al. [60] studied the expression of the gene responsible for Ki-67 (MKi-67 gene) among 473 HCC samples and observed that higher gene expression correlated well with survival parameters, disease stage and progression, adverse histological criteria, and tumor microenvironment proliferative characteristics. This evidence concerns the gene MKI67 and neoplasm.