MKI67 and hepatocellular carcinoma: In order to avoid the heterogeneity—and, hence, inaccuracy—of immunohistochemical analysis, Ramos-Santillan et al. [60] studied the expression of the gene responsible for Ki-67 (MKi-67 gene) among 473 HCC samples and observed that higher gene expression correlated well with survival parameters, disease stage and progression, adverse histological criteria, and tumor microenvironment proliferative characteristics.