The most common LT criteria for HCC are the Paul-Brousse [6], Milan [5], UCSF [7], Up-to-seven [8], Asan [9], CUN (Navarra) [10], Valencia [11], Toso [12], Kyoto [13], Extended Toronto [14], Kyushu University [15], Onaca (ITR) [16], Samsung [17], Metroticket 2.0 model [18], alpha fetoprotein (AFP) model [19], Tokyo (5-5 rule) [20], BCLC [21], Shanghai [22], 5-5-500 rule [23], AFP-TTD [24], Malatya [25], and Expanded Malatya [26] criteria. This evidence concerns the gene AFP and hepatocellular carcinoma.