Collectively, optimal monitoring of KCS2-related hypoparathyroidism to avoid long-term complications requires examining 25–hydroxyvitamin D levels every 6–12 months; serum creatinine, calcium, magnesium, and phosphorus levels every 3–12 months; and the urine calcium/creatinine ratio every 6–24 months [46]. Here, FAM111A is linked to hypoparathyroidism.