CALR and Heart block: Although not specific to RA, testing for anti-Ro/SSA and anti-La/SSB antibodies should be done only once for women with RA during the preconception evaluation and not repeated during pregnancy, as recommended by the 2020 American College of Rheumatology guideline for the management of reproductive health in Rheumatic and Musculoskeletal diseases, as their presence is associated with the risk of foetal heart block and neonatal lupus, especially with a moderate or high titre [21].