mir-222 targets, such as the reversion-inducing cysteine-rich protein with Kazal motifs [22], WEE1 [23], homeodomain interacting protein kinase 2 [24], vestigial-like family member 4 [25], and PTEN [26], modulate the proliferation, invasion, metastasis, and apoptosis of GC cells. The gene discussed is PTEN; the disease is gastric cancer.