Systemic factors encompass components defining an individual’s overall health or disease status that impact their regenerative capacity, including age, gender, stress, biochemical markers (e.g., albumin, C-reactive protein, hemoglobin), chronic diseases (e.g., diabetes, heart failure, renal failure, obesity), medications (e.g., steroids, chemotherapy), addictions (e.g., alcoholism, smoking), conditions impairing immunity (e.g., cancer, radiotherapy), and malnutrition. The gene discussed is CRP; the disease is malnutrition.