CRP and nutritional deficiency disease: Systemic factors encompass components defining an individual’s overall health or disease status that impact their regenerative capacity, including age, gender, stress, biochemical markers (e.g., albumin, C-reactive protein, hemoglobin), chronic diseases (e.g., diabetes, heart failure, renal failure, obesity), medications (e.g., steroids, chemotherapy), addictions (e.g., alcoholism, smoking), conditions impairing immunity (e.g., cancer, radiotherapy), and malnutrition.