ITGB3 and hydrops fetalis: According to the research results, HF patients had more complications, increased changes in biochemical parameters (LDH, hemoglobin, hematocrit, etc.), and found that the TC genotype of polymorphism rs5918 in the ITGB3 gene was significantly higher with thrombosis complications in HF patients with implanted HMII devices than with HM3 devices (p < 0.05).