The average CGM CV% increased from MS- group (21.1%) to the MS+ group (23.9%) and to the MS+/T2D group (27.4%), but it was not correlated with the CGM mean glycemia (r = 0.20; p = ns). Stepwise multiple correlation analysis showed that IL-6 predicted CGM CV% (R(2) = 0.35, beta = 0.13; p < 0.05) independently of BMI, waist circumference, adiponectin and insulin concentrations. Here, INS is linked to type 2 diabetes mellitus.