SMARCB1 and cancer: For instance, inactivating mutations in the SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily b member 1 (SMARCB1) have been identified in pediatric malignancies such as medulloblastoma (MB), atypical teratoid rhabdoid tumors (ATRT), and ovarian carcinomas, which impair cell differentiation and maintains the cancer stem cell-like phenotype [72,73,74,75].