The results indicated that wild-type melanomas enriched genes network modules regulated by genes involved in mitochondrial function; NRAS Q61L melanomas were most enriched for modules regulated by C19orf10, ARF4, KDELR2; BRAF V600K melanomas downregulated modules regulated by ribosomal proteins; and BRAF V600E melanomas were most enriched for modules regulated by processing and trafficking proteins. The gene discussed is ARF4; the disease is melanoma.