BRAF V600E melanomas were most enriched for modules 3 (ALAS1, HMG20B, CALR), 26 (PAN3, CCT2, BTF3), and 27 (MYO1B, USE1, REXO2), and moderately downregulated for module 7 (Figure 3A, B). The gene discussed is USE1; the disease is melanoma.