SPN and melanoma: Analysis of differential MEs revealed module 14 (TLCD2, PRICKLE2-AS3, and SPN) was significantly upregulated by NRAS Q61L melanomas (log2fc = 100.2, adjusted p = 1.32 × 10−2) and downregulated by BRAF V600E melanomas (log2fc = −206.3, adjusted p = 3.51 × 10−14) (Figure 3C).