CD4 and neoplasm: While CD8+ cytotoxic T-lymphocytes within the tumor area were comparable between the TIL-B-rich and TIL-B-poor tumors (Figure 4A), significantly more CD3+ T-lymphocytes were present in TIL-B-rich tumors (p = 0.007) (Figure 4B), suggesting a putative cross-talk between TIL-B and CD4+ (CD3+/CD8−) T-lymphocytes within the tumor microenvironment of OCSCC.