CD4 and neoplasm: To spatially characterize TIL-B infiltration and interaction with other immune subsets, we compared five TIL-B-poor and six TIL-B-rich OCSCC using an m-fIHC panel optimized for tumor cells, CD163+ macrophages, CD4+, CD8+, and FoxP3+ regulatory T-lymphocytes (Figure 5A and Figure 6A,B).