Circulating levels of TSP-2 were confirmed to be a potential diagnostic candidate in pancreatic cancer and lung cancer [24,25,26,27], while the histological expression of TSP-2 has been identified to be an independent prognostic biomarker for distal cholangiocarcinoma, colorectal cancer, and urothelial carcinoma [28,29,30]. This evidence concerns the gene THBS2 and urothelial carcinoma.